News about Medicine (Page 3)

Canadian HealthCare Mall: Cardiorespiratory Fitness

Stroke is the leading cause of serious long-term disability in adults. In the United States, > 700,000 people experience a stroke annually, and approximately 4 million Americans are currently alive after experiencing a cerebrovascular event. Two thirds of individuals require rehabilitation, and the majority of stroke survivors have residual disability, with equal proportions having mild, […]

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Drugs for Sjögren’s Syndrome Treatment – Canadian Health&Care Mall

In 1979, Hunninghake and Fauci in their review entitled “Pulmonary Involvement in the Collagen Vascular Disorders,” suggested that this involvement is frequent in Sjögren s syndrome and can be manifested as pleurisy, interstitial fibrosis, desiccation of the tracheobronchial tree, and lymphoid interstitial disease. They also stated that the first two could be manifestations of the […]

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Human Peripheral Blood and Pleural Fluid Eosinophils: Eosinophils as Effector Cells in Inflammatory and Immune Reactions

Human Peripheral Blood and Pleural Fluid Eosinophils: Eosinophils as Effector Cells in Inflammatory and Immune Reactions

Eosinophils as Effector Cells in Inflammatory and Immune Reactions The list of human disorders associated with an excess of eosinophils in the blood, tissues and secretions includes diseases characterized by IgE-mediated hypersensitivity, such as allergen-induced bronchial asthma, allergic rhinitis and allergic bronchopulmonary aspergillosis, infections with metazoan parasites, certain drug reactions, a number of connective tissue […]

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Human Peripheral Blood and Pleural Fluid Eosinophils: Discussion

Although eosinophils are common components of a variety of inflammatory and immune-mediated responses, which role they may play in many pulmonary and pleural diseases is unclear. However, since these diseases often are characterized by injury to parenchymal cells and since eosinophils, when activated, can secrete a variety of cytotoxic products, it is reasonable to hypothesize […]

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Figure 4. Reduction of eosinophil (A)- and neutrophil ('Bj-mediated Raji cell injury by catalase. Human peripheral blood eosinophils (open circles) or neutrophils (open triangles) from three normal subjects, activated by PMA (75 ng/ml), were incubated at increasing effector-to-target ratios with Cr-labeled Raji cells for 4 h alone (open symbols) or in the presence of catalase 1000 U/ml (solid symbols). Each data point represents the mean ± SEM of three different experiments.

Human Peripheral Blood and Pleural Fluid Eosinophils: Ability of Catalase to Inhibit Eosinophil and Neutrophil Cytotoxic Activity

Ability of Catalase to Inhibit Eosinophil and Neutrophil Cytotoxic Activity To demonstrate that the cytotoxic damage induced on Cr-labeled Raji cells by stimulated eosinophils and neutrophils was mostly related to the generation of H202, various numbers of peripheral blood or pleural fluid leukocytes were cocultured with the target cells in the presence of PMA, IgG […]

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Human Peripheral Blood and Pleural Fluid Eosinophils: Cytotoxic Activity of Peripheral Blood Eosinophils and Neutrophils from Control Subjects

Cytotoxic Activity of Peripheral Blood Eosinophils and Neutrophils from Control Subjects Peripheral blood eosinophils and neutrophils from control subjects exhibited a very low spontaneous cellular cytotoxicity for Cr-labeled Raji cells after 4 h incubation (Fig 2). In contrast, stimulation of the cells with PMA induced a detectable eosinophil- and neutrophil-mediated killing which increased directly, for […]

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