News about Medicine - Part 2

My Canadian Pharmacy: Emotionally Unstable Personality Disorder

Emotionally unstable personality disorder is a state at which at the patient the expressed impulsiveness, unbalance are shown. At the same time to the patient it is very difficult independently to control such manifestations. People with this disorder are inclined to actions without their consequences, they have always an unstable mood, and strong affective flashes can arise because of the smallest occasion. By estimates of experts, this disorder is noted at 2-5% of the population. More often the illness affects women. Experts allocate two types of such frustration:

  • impulsive type;
  • boundary type.

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Interesting Facts with My Canadian Pharmacy

pharmacyThere are various interesting facts about medicine and pharmacy. My Canadian Pharmacy (mymedstorecanada) makes up its mind to tell you some interesting facts concerning medicine. Medicine is a science directed to treat people from various diseases. There are different operations conducted during treatment. Let’s grapple with some facts which attract our attention.

  1. In 1980 the most high temperature of body was defined. In Atlanta, the State of Washington, at the inhabitant Willy Jones at receipt in clinic body temperature made 46,5 degrees!!! But, fortunately, everything managed, and in 24 days it was written out.
  2. And on February 23, 1994 physicians faced one more anomaly: the 2-year-old inhabitant of Canada Carly Kozolofski had record-breaking low body temperature. It made only 14,2 degrees. All the matter is that the house door where this child lived, was incidentally closed, and he spent the whole 2 hours on 22-degree frost.
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Propecia Sold by My Canadian Pharmacy

Propecia

Propecia. Specificity

Propecia is medical preparation for treatment of the male pattern baldness. Some years of investigation and use of preparation it turns out more than one million patients show that Propecia is intended for a long-term use, it is effective and safe in treatment of male pattern baldness, irrespective of national identity.

Active ingredient is finasteride, enzyme antagonism turning testosterone into its active form – dihydrotestosterone. Finasteride is applied since 1992 in urological practice as treatment of good-quality prostatic hyperplasia. In 1998 efficiency of small doses of the same substance (1 mg/days) concerning growth of hair was proved. This preparation is available on My Canadian Pharmacy – http://my-medstore-canada.net/.

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Canadian Neighbor Pharmacy: IAB and Arrhythmias

Left Ventricular FunctionLeier and colleagues showed that prolonged atrial conduction was a predisposing factor for development of atrial flutter as early as 1978.

Kumagai and colleagues used multisite mapping studies confirming findings of a previous study by Ogawa and colleagues. They concluded that the mechanism of atrial arrhythmias was indeed aberrant impulse conduction between the atria along interatrial pathways, mainly the BB. Duytschaever and colleagues then successfully reproduced this mechanism in animal studies. In another series, Giudici and colleagues investigated 21 patients with uncontrolled atrial fibrillation who underwent atrioventricular nodal ablation and permanent pacing. They showed that when the leads were placed in the BB, atrial conduction times were decreased.

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Canadian HealthCare Mall: Discussion of Thoracentesis in Patients With Hematologic Malignancy

LymphomaPleural effusions occur regularly during the hospitalization of patients with hematologic malignancies, and thoracentesis is frequently performed. Most of the effusions in which a thoracentesis was undertaken were moderate to large in size (87%) and were associated with parenchymal pulmonary abnormalities (69%). Both bilateral effusions (62%) and unilateral effusions (38%) were subject to thoracentesis. Although fluid overload, cardiac dysfunction, and hypoalbuminemia were a concern in this population, only 10% of the effusions that had been analyzed using thoracentesis were documented to be transudates. Exudates were documented in 83% of patients, and 7% were unclassified because of a lack of data. A specific etiology for the effusions was identified in only 21 patients, with 20 effusions due to malignancy or chylous effusions, while only 1 effusion was due to infection. The yield for a malignant or chylous effusion was highest in patients with lymphoma (yield, 31%) compared to the other patient groups. This higher yield is not unexpected since, among the hematologic malignancies, lymphomas have been most commonly associated with the development of malignant effusions. In patients with Hodgkin lymphoma and non-Hodgkin lymphoma, pleural involvement due to the underlying disease is seen in up to 20 to 30% of patients, while malignant involvement is much less common in patients with the acute and chronic leukemias.

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Canadian Neighbor Pharmacy: Discussion of Diaphragmatic Fatigue and Breathing Pattern during Weaning from Mechanical Ventilation in COPD Patients

respiratory failureOur study brings out the following two important findings: (1) on patients with COPD disconnected from mechanical ventilation and showing no sign of respiratory failure within two hours, the values of Vmin, VtAR, P01, pH, Pa02, and PaC02 did not provide any clue as to the final success or failure of medium-term weaning (ten hours); and (2) due to the low value of the Pdimax, the Pdi/Pdimax ratio was higher on the group that failed to be weaned within ten hours. In addition, that same group showed a negative Pga in 16/19 trials, which never occurred in the other group.

In a previous paper, we showed that the patients who had to be reconnected to mechanical ventilation within ten hours showed no initial difference in their breathing pattern compared with the others. Only later, and particularly after two hours, did changes occur that suggested a quicker deterioration of the pulmonary mechanical condition. On the present study, the differences between our groups after two hours were not really significant except for a shorter TVTtot ratio (p<0.01), a result probably due to a central type adaptation to compensate for the imposed extraload. On the contrary, the signs of diaphragmatic dysfunction occur earlier and are easily exposed, but their meaning is less clear.

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Canadian Neighbor Pharmacy: Transbronchial Needle Aspiration in the Diagnosis of Endobronchial Malignant Lesions

Transbronchial needle aspirationTransbronchial needle aspiration (TBNA) is a beneficial, safe, and minimally invasive bronchoscopic technique used in the diagnosis and staging of bronchogenic carcinoma. It was first introduced by Wang et al in the late 1970s. This method is usually performed through a flexible bronchoscope and provides cytologic or histologic sampling of mediastinal lesions that lie adjacent to the tracheobronchial tree. Previously, the utility of TBNA was restricted to mediastinal lymph node and extrabronchial lesion sampling. Its use has been expanded to complement conventional diagnostic techniques (CDT) such as bronchial washing (BW), bronchial brushing (BB), and forceps biopsy (FB) in the diagnosis of lung cancer with endobronchial lesions.

Central bronchogenic carcinoma tends to manifest in one of three patterns. The growth may be predominantly in the mucosal layer, in which case the tumor presents as a bulky, exophytic mass. It can also spread predominantly in the submucosa, with endoscopic findings consisting of erythema, loss of the normal bronchial markings, narrowing of the bronchus, or thickening of the mucosa. The third pattern is that of a predominantly peribronchial spread, in which the endoscopic findings are usually narrowing of the airway due to extrinsic compression of the bronchus. Particularly in the presence of peribronchial and submucosal lesions, diagnosis with CDT such as BW, BB, and FB is more difficult. However, applying a needle into the lesion provides access to lower layers of the bronchus and adjacent lesions. Despite its advantages in diagnosis, TBNA is still an underutilized procedure in many centers because of the risk of damage to the bronchoscope, need for experienced staff, and high cost. This is a retrospective study carried out in our clinic to investigate the diagnostic yield of TBNA and its contribution to CDT in lung cancer patients.

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