Category: Surgical Patients

Comparison of Hemodynamic and Oxygen Transport Effects of Dopamine and Dobutamine in Critically Ill Surgical Patients: Conclusion

Pretrial and post-trial baseline hemodynamic values were essentially within normal limits but considerably below the optimal values empirically determined from critically ill postoperative survivors (Cl, 4.5 L/min/sq m; Do2, 600 ml/min/sq m; Vo2, 170 ml/min/sq m). Although about 75 percent of the postoperative patients achieved these goals with only therapy with fluids, all of the […]

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Comparison of Hemodynamic and Oxygen Transport Effects of Dopamine and Dobutamine in Critically Ill Surgical Patients: Materials and Methods

Comparison of Hemodynamic and Oxygen Transport Effects of Dopamine and Dobutamine in Critically Ill Surgical Patients: Materials and Methods

Clinical Series The study was approved by the institutions Human Subjects Review Committee, and each patient or the next of kin signed an informed consent. Studies were performed on 25 critically ill general surgical patients; Table 1 summarizes the salient clinical features. Each patient was given dopamine and dobutamine; the allocation of the first drug […]

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Comparison of Hemodynamic and Oxygen Transport Effects of Dopamine and Dobutamine in Critically Ill Surgical Patients: Circulatory

The increased cardiac output was associated with reduced PAWP after dobutamine but with increased PAWP after dopamine. Improvement in tissue perfusion indicated by increased Do2 and Vo2 were demonstrated after various doses of dobutamine in critically ill general surgical patients; however, in patients with sepsis, Jardin et al found dobutamine reduced C(a-v)02 but did not […]

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Comparison of Hemodynamic and Oxygen Transport Effects of Dopamine and Dobutamine in Critically Ill Surgical Patients

Comparison of Hemodynamic and Oxygen Transport Effects of Dopamine and Dobutamine in Critically Ill Surgical Patients

Both dopamine, a naturally occurring catecholamine, and dobutamine, a synthetic catecholamine, have powerful positively inotropic, mild chronotropic, arrhythmogenic, and vascular effects. Dopamine raises arterial pressure by its a-adrenergic effect, but both catecholamines augment myocardial contractility by stimulation of (3-adrenergic receptors. Dobutamine is unique in that it has two stereoisomers: the (-)-isomer is more potent than […]

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