Archive for the ‘Skin Diseases’ Category

Henoch-Schönlein Purpura

Henoch-Schönlein Purpura

Henoch-Schönlein purpura, also referred to as anaphylactoid purpura is a systemic vasculitis syndrome characterized by palpable purpura (usually distributed over the buttocks and lower extremities), arthralgias, gastrointestinal signs and symptoms, and glomerulonephritis. It is a small vessel vasculitis.

Incidence And Prevalence

Henoch-Schönlein purpura is usually seen in children, age from 4 to 7 years; however, the disease may also be seen in infants and adults. It is not a rare disease, accounting for approximately 5 and 24 admissions per year at one pediatric hospital. The male to female ratio is 1.5:1. A seasonal variation with a peak incidence in spring has been noted.

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Henoch-Schönlein Purpura

Henoch-Schönlein purpura - Wikipedia, the free encyclopedia

Henoch-Schönlein purpura, also referred to as anaphylactoid purpura is a systemic vasculitis syndrome characterized by palpable purpura (usually distributed over the buttocks and lower extremities), arthralgias, gastrointestinal signs and symptoms, and glomerulonephritis. It is a small vessel vasculitis.

Incidence And Prevalence

Henoch-Schönlein purpura is usually seen in children, age from 4 to 7 years; however, the disease may also be seen in infants and adults. It is not a rare disease, accounting for approximately 5 and 24 admissions per year at one pediatric hospital. The male to female ratio is 1.5:1. A seasonal variation with a peak incidence in spring has been noted.

Pathophysiology And Pathogenesis

The presumptive pathogenic mechanism for Henoch-Schönlein purpura is immune-complex deposition. A number of inciting antigens have been suggested including upper respiratory tract infections, foods, insect bites, and immunizations. IgA is the antibody class most often seen in the immune complexes and has been demonstrated in the renal biopsies of these patients. Read the rest of this entry »

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