Category: hepatitis С

Management of Recurrent Hepatitis C Following Liver Transplantation: Summary

Recurrent HCV is a major cause of allograft loss and mortality in liver transplant recipients with chronic HCV infection. The development of strategies designed to optimize patient and graft survival in this population is critical, as HCV is currently the most common indica­tion for liver transplantation. A greater understanding of the risk factors for progressive […]

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Management of Recurrent Hepatitis C Following Liver Transplantation: Repeat Liver Transplantation

Ultimately, repeat liver transplantation may be considered in select patients with HCV recurrence and allograft fail­ure. Although prior data have identified HCV infection as an independent predictor of mortality following retrans- plantation, more recent reports have described similar rates of survival in HCV and non-HCV recipients. A key factor associated with the observed improvement in […]

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Management of Recurrent Hepatitis C Following Liver Transplantation: Immunosuppression

Immunosuppressive regimens initiated at the time of liver transplantation, as well as methods of treating acute cellular rejection during the post-transplant course, appear to have a significant role in the development of liver disease associated with HCV recurrence. Consequently, several strategies have emerged with the goal of minimizing the negative impact of high-dose or pulse […]

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Management of Recurrent Hepatitis C Following Liver Transplantation: Antiviral Therapy

Treatment Before Transplantation Although PegIFN in combination with RBV remains the gold standard for the treatment of chronic HCV infec­tion in the pretransplant setting, long-term viral sup­pression can be achieved in only approximately one half of patients. Antiviral therapy in patients with HCV cirrhosis awaiting liver transplantation should be consid­ered in select individuals; however, poor […]

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Management of Recurrent Hepatitis C Following Liver Transplantation: Hepatitis C and the Transplanted Liver

Recurrence of Chronic Infection Recurrence of hepatitis C viremia following liver trans­plantation occurs in all patients with chronic HCV infec­tion who have detectable serum HCV RNA levels prior to transplant. A significant decline in serum HCV RNA levels has been observed during the anhepatic phase of transplantation and immediately following reperfusion of the allograft; however, […]

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