Archive for the ‘Benzodiazepine’ Category

Population trends in the prevalence of benzodiazepine use: DISCUSSION(5)

DISCUSSION(5)

However, because the general prevalence of sleep disorders in the senior population is approximately 12% and the prevalence of symptoms of anxiety is approximately 10% to 20%, it appears that the overall level of benzodiazepine use may be higher than necessary, although this inference needs to be confirmed with accurate diagnostic and medication data.

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Population trends in the prevalence of benzodiazepine use: DISCUSSION(4)

Attempting to estimate the daily doses of benzodiazepines used by the older population in this study for comparative purposes was not successful. The estimates yielded unforeseeable and unacceptable levels of variations between individual daily doses. This disappointing result may be due to several factors, including inconsistencies in coding of days’ supply by the pharmacist in instances where the prescribed directions for use were ‘as directed’ and by varying levels of benzodiazepine use by the patients. Unfortunately, specific directions for use are not part of the electronic claim and, thus, not captured in the database. Other investigators have noted similar limitations when using administrative databases for dosing information . This is an important gap in the information on the administrative database available for this study, which clearly raises a question as to the usefulness of this type of administrative database for estimating daily doses of pharmaceuticals used by the population covered by Phar-macare. Find best deals online – ventolin inhalers can be available every time you visit.

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Population trends in the prevalence of benzodiazepine use: DISCUSSION(3)

DISCUSSION(3)

Which benzodiazepines, if any, are safe for use in older people remains a matter of controversy. Some authors consider triazolam to be inappropriate for use in older people because its use has been reported to be associated with significant cognitive disruptions . Although the relative safety of triazolam remains controversial , previous studies of triazolam in elderly people have documented a decreased clearance , as well as increased sway and excessive motor impairment (ie, altered pharmacokinetics and pharmacodynamics), making the use of this drug in this population less appealing. Similarly, geriatric pharmacology textbooks and reviews suggest that only benzodiazepines that are metabolized by glucuronidation should be used in elderly people because their metabolism is generally unaffected by age (in contrast to some short half-life benzodiazepines such as triazolam, bromazepam and alprazolam, whose clearance is affected with aging) . Last, because the dose of benzodiazepine used may be more important than elimination half-life, as suggested by Herings et al , this also becomes an important issue in the clinical use of these drugs. You can be sure your pharmacy offers Buy Cheap Claritin delivering fast internationally.

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Population trends in the prevalence of benzodiazepine use: DISCUSSION(2)

The proportion of benzodiazepine prescriptions filled in Nova Scotia in 1993/96, which are considered to be inappropriate for use in the elderly (ie, long elimination half-life benzodiazepines) based on published criteria (which have been available since 1991), was 24% (of filled benzodiazepine prescriptions) in 1993/94 and 1994/95, and 23% in 1995/96 . However, the overall prevalence of benzodiazepine use decreased from 7% of seniors in 1993/94 to 5.7% of seniors in 1995/96 (Table 1).

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Population trends in the prevalence of benzodiazepine use: DISCUSSION(1)

DISCUSSION(1)

Hogan et al analyzed data from the 1990 CSHA, and reported that 5.2% of the sample were using long half-life benzodiazepines and that 18.1% were using short half-life benzodiazepines. It was also reported that living in Quebec, and not living in Ontario or the Prairies increased the probability of inappropriate benzodiazepine use . Tamblyn et al , using the provincial Regie de l’assurance-maladie du Quebec database, reported that, in 1990, 13% of seniors were using long-half life benzodiazepines . Our findings that 5.7% and 18.9% of Nova Scotia seniors were using long or short half-life benzodiazepines, respectively, in the fiscal year 1995/96 are comparable with those reported by Hogan et al . You always want to be sure that drug works for you and still does not cost too much? Then you should definitely shop with cialis professional 20 mg always getting the exact quality you wanted for less money than anywhere else.

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Population trends in the prevalence of benzodiazepine use: SUBJECTS AND METHODS(4)

In each fiscal year, benzodiazepines with short elimination half-lives were more commonly filled than those with long elimination half-lives. Long elimination half-life benzodiazepines accounted for 24% of benzodiazepine prescriptions filled in the fiscal years 1993/94 and 1994/95, and 23% in the fiscal year 1995/96. The most commonly filled short half-life benzodiazepines were lorazepam, temazepam and oxazepam, which accounted for 34%, 11% and 10% of benzodiazepine prescriptions in each of the fiscal years 1993/94, 1994/95 and 1995/96, respectively. You have a chance to fight off the disease by taking the exact medicine you need at the exact amount required. Visit the best canadian family pharmacy and find the drug required available at a very appealing price with fast shipping.

The proportion of benzodiazepine prescriptions filled for periods exceeding 30 days increased significantly during the study period from 65% to 67%, and 68% in the fiscal years 1993/94, 1994/95 and 1995/96, respectively (P<0.001 for all comparisons). However, the overall prevalence of benzodiazepine use for periods exceeding 30 days decreased significantly from 18.66% of seniors in 1993/94 to 16.82% of seniors in 1994/95 and 1995/96, respectively (P<0.001). When the proportion of seniors using benzodiazepines for extended periods was recalculated using 90 days as the cutoff point, the use of benzodiazepines further declined to 11.39%, 10.01% and 9.61% of seniors in fiscal years 1993/94, 1994/95 and 1995/96, respectively (P 0.001). Long half-life benzodiazepines were less likely to be used for more than 30 days than short half-life benzodiazepines (relative risk [RR] 0.96 [95% CI 0.95 to 0.98] in the fiscal year 1993/94, RR 0.95 [95% CI 0.93 to 0.97] in the fiscal year 1994/95 and RR 0.97 [95% CI 0.95 to 0.98] in the fiscal year 1995/96).

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Population trends in the prevalence of benzodiazepine use: SUBJECTS AND METHODS(3)

SUBJECTS AND METHODS(3)

The duration of prescriptions was determined by calculating the days between the beginning dates of the first and last prescription, and adding the days’ supply of the last filled prescription. For example, if a person filled a prescription on January 1 for a 60-day supply of a benzodiazepine, then filled another prescription for a 20-day supply on March 1, the duration is calculated as 60 days (period between March 1 and January 1) plus 20 days (days’ supply of the last filled prescription), for a total duration of 80 days. Only the first observation in the fiscal year of a prescription exceeding 30 days’ duration was counted for a particular prescription. The proportion of individuals filling prescriptions for periods exceeding 30 days was calculated by dividing the number of individuals with a prescription filled for greater than 30 days’ duration by the total number of individuals who filled a prescription for a benzodiazepine. Most reliable pharmacy can offer Claritin online tablets always charging you a lot less.

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