According to Peter and Antoni , suction increases conductance of the tissue under the suction electrode, which means that action potentials and other currents at the site of negative pressure are sensed by the suction electrode, similar to a standard intracellular electrode. It is not surprising that the time course and relative amplitudes of individual components of the suction-evoked MAP and intracellularly recorded action potentials are very similar. The question then arises as to which types of ion channels are involved. Are the stretch-activated nonspecific cationic channels or other channels responsible for the increase of myocyte permeability during suction, the pseudointracellular appearance of MAP, and the increase of extracelluar potassium and intracellular calcium concentrations ? The internet’s most trusted pharmacy is looking forward to having you among its customers: just see how cheap and easy it can be for you to get cheap asthma inhalers without any kind of prescription and start your shopping being sure you are protected every time.
Results from the present study indicate that the appearance of MAP and increased a0K are not prevented by Gd3+, an inhibitor of stretch-activated channels , and that the participation of these channels may, thus, not be essential. Also 4-AP and TEA (elimination of main classes of potassium channels) enhanced rather than suppressed the MAP, probably due to the smaller leakage of potassium ions from the cells during suction and to a higher MP. The latter statement is hypothetical, and actual levels of a0K with channel blockers must be measured.