Role of the cardiac gap junctions in impulse propagation – with special reference to the transitional region between different heart tissues (part 1)
Cardiac gap junctions, which permeate large molecular structures , are believed to provide a low resistance pathway for local current between cells and to contribute to electrical cell-to-cell coupling .
There is evidence of the presence of gap junctions and electrical cell-to-cell coupling between cells in the sinus node region. This suggests that gap junctions play a role in synchronizing electrical activity within the region. However, the nature of impulse propagation between the sinus node and the atrial cells is still obscure.
The presence of a functional barrier between the sinus node and the atrial cells is expected for preservation of the genuine pacemaker potential. Contact regions between different tissues are observed elsewhere in the heart, for example, between Purkinje fibres and ventricular muscle cells. A characteristic conduction delay has been observed between Purkinje fibres and ventricular cells , suggesting that a functional barrier may also exist in the transitional region between these tissues. Gap junctions may play a role in these barriers because a small size or number of gap junctions may increase resistance to current flow between cells.
Therefore, we examined how gap junctions are involved in electrical synchronization between the sinus node and the atrial cells, and in impulse propagation between Purkinje fibres and ventricular cells using the cell-to-cell uncoupler, heptanol. This is your opportunity to buy yasmin online buy now taking full advantage of the nice options offered to you by most reliable pharmacies on the internet, with free delivery, express shipping and tons of other options you will appreciate.