Endothelium-derived nitric oxide is not altered in vivo in fructose-hypertensive rats (part 5). RESULTS

Responses to ACh before and after L-NAME administration in control and fructose-hypertensive rats: Ach-induced hypotensive responses did not differ between the control and fructose-hypertensive groups either before L-NAME administration (12.6±1.5 mmHg versus 10.4± 1.2 mmHg at 0.1 mg/kg dose, and 28.8±2.4 mmHg versus 27.8±2.5 mmHg at 0.5 mg/kg dose) or after L-NAME administration (16.4±1.9 mmHg versus 17.3±2.3 mmHg at 0.1 mg/kg dose, and 34.2±1.4 mmHg versus 33.0±2.8 mmHg at 0.5 mg/kg dose) as shown in Figure 1. The fall in blood pressure increased in a dose-dependent manner. Infusion of L-NAME caused a steady, sustained rise in blood pressure of approximately 20 mmHg in both groups (data not shown). Following this elevation, responses to further ACh injections were increased inboth groups (as shown by preceding data).Duration of responses to ACh before and after L-NAME administration in control and fructose-hypertensive rats: Atboththe0.1 mg/kg and 0.5 mg/kg doses of ACh (before L-NAME administration), a two-phase vasodilator response was observed in both groups. There was an initial, rapid decrease in blood pressure followed by a delayed, smaller response (Figure 2, top).

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Figure 1 Absolute change in blood pressure response to acetylcholine in control (n=9) and fructose-hypertensive (n=9) rats. L-NAMEN® -nitro-L-arginine methyl ester

Endothelium-derived nitric oxide is not altered in vivo in fructose-hypertensive rats

Figure 2 Top Acetylcholine (ACh)-inducedresponse in cannulated artery of anesthetized rat before N® -nitro-L-arginine methyl ester (L-NAME) administration. Phase (a) represents the initial, rapid fall in blood pressure and (b) represents the smaller, delayed phase of the response at a dose of 0.5 Jg/kg. Bottom ACh-induced response in cannulated artery of anesthetized rat after L-NAME administration. Phase (a) depicts the initial, rapid fall in blood pressure, while (b) depicts a transient, hypertensive response at the dose of 0.5 Jg/kg 

 

 

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