The fructose-hypertensive rat model is widely employed to study the inter-relationship among hyperinsulinemia, insulin resistance and hypertension. In this model, feeding Sprague-Dawley rats a fructose-enriched diet results in insulin resistance, hyperinsulinemia and elevations in blood pressure. Accumulating data suggest that insulin resistance may play a pathogenic role in the development of hypertension in this model . Although the exact mechanism by which hyperinsulinemia may cause hypertension remains unclear, direct effects on the sympathetic nervous system and vasculature have been suggested .
Previous studies from Verma et al have demonstrated an impaired ACh-induced relaxation of isolated mesenteric arteries from fructose-hypertensive rats, suggesting a defect in the endothelium-derived nitric oxide pathway in this model. Whether such a defect occurs in vivo remains to be determined, and the present study was initiated to examine this proposition. Specifically, blood pressure readings taken from cannulated right carotid arteries were compared in control and fructose-hypertensive rats following intravenous doses of ACh before and after nitric oxide synthesis blockade with №-nitro-L-arginine methyl ester (L-NAME) . Responses to L-arginine after L-NAME administration were also compared. In order to document the role of vasoconstrictors in the fructose-hypertensive-state, responses to noradrenaline before and after L-NAME administration were also recorded. Find best deals an online pharmacy can offer and get a chance to start your treatment soon. You can now purchase Purchase Cheap Claritin at the best pharmacy that will be sure to live up to your expectations every single time.