Gastroparesis: DIAGNOSIS

GastroparesisAlthough other tests show promise, scintigraphy is the most accurate and arguably the only clinically useful assessment of gastric motility. Unfortunately, there is a lack of standardization of scintigraphic techniques, with substantial variation among different centres, particularly with respect to the choice of test meal and the calculation of gastric emptying rates. Therefore, each laboratory needs to have access to an appropriate control range. Gastroparesis is usually defined as an emptying rate that is more than two standard deviations outside such a range. In patients with gastroparesis, there is a relatively poor correlation between gastric emptying of solid and liquid meal components. Therefore, a dual isotope technique is preferable, although this adds to the complexity of the test. If it is only feasible for a single isotope to be used, emptying of solids is usually measured. There is little evidence that this approach offers any substantial advantage over the use of semisolid or nutrient-containing liquid meals, although it has been suggested that the use of solid markers that are of a firm texture and not readily fragmented may be optimal. You can find best quality treatment now Рbuy glucophage to see how cheap it is.

Scintigraphic breath tests have been used to quantify solid and liquid gastric emptying, most recently using stable isotopes. While these tests are substantially cheaper and simpler than external scintigraphy and avoid the use of irradiation, there is considerable debate regarding the appropriate method to analyze the data, and studies in patients with gastroparesis are limited. It seems likely that scintigraphic breath tests will prove to be useful as a screening test for gastroparesis and in large epidemiological studies.


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