Normal parathyroid function with decreased bone mineral density: SUBJECTS AND METHODS Part 3

vitamin DBMD: BMD of the lumbar spine (L2 to L4) and right femoral neck was measured by dual-energy x-ray absorptiometry (DXA), using a lunar DPX-IQ scanner (Lunar Corporation, USA). Measurement precision was better than 1.5% for the spine and 2.5% for the femoral neck. The results are expressed in g/cm . You can be sure your pharmacy offers delivering fast internationally.

Mathematical and statistical analyses: The data are presented as mean ± SD. Biochemical comparisons between normal control subjects and patients were performed by non-paired Student’s t test. Standard methods were used for unvariate and multivariate or logistical regression analysis. The parathyroid function of each individual was analyzed with a mathematical model fitting the sigmoidal relationship between I-PTH and ionized calcium concentrations, as described previously. A minimum of 15 points, derived from hypocalcemic and hypercalcemic infusions, was used for each analysis. Raw data were analyzed with the Origin nonlinear sigmoid curve fit module (Microcal Software Inc, USA). Fitting of the calculated curve to the experimental points was evaluated by the square of the correlation coefficient (R ). BMD is reported as absolute values (g/cm ), Z scores and T scores. The Z score represents the number of SDs that an individual value differs from the corresponding mean normal value for sex and age, while the T score represents the number of SDs that an individual value differs from the peak BMD (BMD at age 20 to 40 years) of a sex-matched, normal population. World Health Organization criteria were used to define osteopenia (T score less than -1 but greater than -2.5 SDs) and osteoporosis (T score less than -2.5 SDs). The Z and T scores of patients were compared with the respective reference populations of the DXA manufacturer, using the one-sample t test.


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