Biochemical parameters and parathyroid function: The main characteristics of all normal control subjects and patients and of those who participated in the parathyroid function study are enumerated in Table 1. The biochemical parameters were similar in the two groups except for I-PTH values, which were higher in patients but still within the normal range (Figure 1). Mean 25-hydroxy vitamin D and 1,25-dihydroxy vitamin D values were also normal in patients, but three of them had 25-hydroxy vitamin D values below 35 nmol/L, the lower limit of the normal range. Findings in the two subgroups studied for parathyroid function were similar, illustrating that the higher I-PTH levels in patients were independent of age and sex. The results of parathyroid function are presented in Table 2 and illustrated in Figure 2 as means for each group. Stimulated I-PTH (maximum), nonsuppressible I-PTH (minimum), sensitivity to calcium changes (slope) and set point (ionized calcium values corresponding to half-stimulation) were similar in both groups.
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Characteristics of patients with celiac disease and normal controls in the basal state (mean ± SD)
*Normal control subjects (all) versus patients (all): P<0.01; fNormal control subjects (all) versus patients (all): P<0.001; *Normal control subjects (parathyroid function group) versus patients (parathyroid function group): P<0.05. I-PTH Intact parathyroid hormone
Figure 1) Levels of intact parathyroid hormone (I-PTH) in 26 normal control subjects and 17 patients with biopsy-proven celiac disease, and in seven patients and seven normal control subjects who underwent parathyroid function study. The normal range is indicated by widening of the scale
Parathyroid function in patients with celiac disease and normal control subjects
|Assay or ratio||Functionparameters||Normals (n = 7)||Patients (n = 7)|
These data are also illustrated in Figure 2. I-PTH Intact parathyroid hormone
Figure 2) Mean parathyroid function in normal control subjects (-) and patients (—-) measured by an intact parathyroid hormone (I-PTH) assay