Gastroparesis: PREVALENCE AND ETIOLOGY Part 2

GastroparesisThe most common causes of chronic gastroparesis are diabetes mellitus, functional dyspepsia, gastroesophageal reflux disease and postsurgical delayed gastric emptying. Although the number of population-based studies is limited, many of the disorders associated with chronic gas-troparesis are associated with a high prevalence of delayed gastric emptying of solids when measured scintigraphically; gastric emptying is delayed in 30% to 50% of patients with functional dyspepsia, longstanding diabetes mellitus or gastroesophageal reflux disease. It should be recognized that the magnitude of the delay in gastric emptying is often relatively modest in these patients, and it has been suggested that a distinction should be made between ‘gastroparesis’ and ‘delayed gastric emptying’; ie, a diagnosis of gastroparesis is restricted to patients in whom emptying is grossly delayed. Moreover, there is evidence in patients with functional dyspepsia that the gastric emptying rate may also be associated with demographic factors, including sex and body weight. It is well recognized that gastroparesis may be a complication of malignancy in the absence of gastric or intestinal obstruction, particularly in association with carcinomas of the pancreas, lung and breast. Chronic gastroparesis commonly accompanies diseases that cause motor dysfunction throughout the gastrointestinal tract. Hence, it is not unusual for esophageal, small intestinal and colonic motility to be abnormal in patients with gastroparesis. Gastric surgery, often involving vagal interruption, gastric resection or a drainage procedure, may be associated with both delayed and more rapid gastric emptying, which cannot be discriminated on the basis of symptoms. Infection with Helicobacter pylori does not appear to cause gastroparesis. Delayed gastric emptying occurs frequently in patients with anorexia nervosa, although it is uncertain whether this is a cause or a consequence of the condition; emptying often improves with recommencement of a significant nutritional intake and precedes significant weight gain. Learn how to save money – buy antibiotics online to enjoy your shopping and your treatment.

Category: Gastroparesis

Tags: Gastric emptying, Gastroparesis

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