Continuous Nebulization of Albuterol (Salbutamol) in Acute Asthma: MEASUREMENTS

Spirometry was performed prior to commencing nebulizer therapy and at 30-minute intervals for 2 hours thereafter. Tests were done using a Vitalograph model S with PFT printer (Lenexa, Kan). FEV„ FVC, and FEF25-75% were determined from the best of three expiratory maneuvers (sum of FEV, and FVC). Pulse, respiratory rate, and blood pressure were measured every 30 minutes for 2 hours. Hand tremor was assessed subjectively by the investigators as absent, mild, moderate, or severe.

Sample Size

The assumptions for sample size determination were based on data obtained in our Emergency Department as well as in other institutions. The FEV, variability was estimated at 23 percent and the difference in efficacy to be detected between groups was 20 percent. The alpha level was set at 0.05 and a power of 80 percent was specified. Under these circumstances a sample size of 21 patients in each group was appropriate for this study. Baseline com­parison of FEV, measurements was assessed by the unpaired Students t test. The one factor analysis of variance (ANOVA) for repeated measures with one grouping factor (mode of therapy) and one within factor (time) was used to compare change in pulmonary function over time with each mode of nebulization. Toxic effects were assessed by the same techniques. Tremor was analyzed using x2– When ANOVA results were significant (p<0.05) the Newman Keuls test was used to test equality of means. suhagra

A p value of 0.05 or less was considered statistically significant. All data are reported as mean ± 1 SD.


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