Physical Compatibility of Pantoprazole with Selected Medications

pantoprazole

INTRODUCTION

Pantoprazole was the first proton-pump inhibitor for IV administration marketed in Canada. It is indicated when a rapid reduction in gastric acid secretion is required for patients who cannot tolerate oral medications; it has recently been approved for the treatment of Zollinger-Ellison syndrome.

It is also administered by continuous IV infusion for control of acute upper gastrointestinal bleeding, although it is not approved for this indication. Because patients receiving IV pantoprazole may be receiving other medications and solutions by the IV route, the potential exists for incompatibility when the pantoprazole is co-infused with other drugs via Y-site administration.

A review of the product monograph, a search of the MEDLINE, International Pharmaceutical Abstracts (IPA), and EMBASE bibliographic databases, and communication with the manufacturer’s medical information department revealed no information about Y-site compatibility with other medications. Compatibility information is limited to that found in the product monograph, which indicates that pantoprazole may be reconstituted with 0.9% sodium chloride for injection (NS) and further diluted with either NS or dextrose 5% in water (D5W) for injection. The objective of this study was to determine, by visual observation during simulated Y-site administration, the physical compatibility of pantoprazole sodium a 0,3 %, jusqu’a 12 heures a 23 °C au cours d’une administration simulee dans un raccord en Y. La formation d’un precipite est survenue avec les melanges de pantoprazole et de norepinephrine ou de dobutamine. On a observe un changement de couleur et la formation d’un precipite lorsque le pantoprazole etait melange a l’esmolol, au midazolam ou a l’octreotide. Regle generale, les melanges de pantoprazole et de dobutamine, d’esmolol ou de midazolam etaient physiquement incompatibles dans un eventail de concentrations cliniquement utiles. L’octreotide et le pantoprazole etaient physiquement compatibles lorsque la concentration d’octreotide etait inferieure a 1,5 pg/mL. La norepinephrine s’est revelee physiquement compatible avec toutes les concentrations de pantoprazole, lorsque ses propres concentrations etaient inferieures a 13 pg/mL. levitra 20 mg

Category: Drugs

Tags: compatibility, dobutamine, esmolol, midazolam, norepinephrine, octreotide, pantoprazole, Y-site

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