HEMOGLOBINOPATHY AND PATTERN OF MUSCULOSKELETAL INFECTION IN CHILDREN

hemoglobinopathy

INTRODUCTION

Bacterial MSS infections—including osteomyelitis, pyomyositis, and pyogenic arthritis, among others—are important causes of morbidity in children. Morbidity in these conditions may be increased by hemoglobinopathies.

SCD is a genetic disorder that is known to be associated with an increased susceptibility to bacterial infections. Many reasons have been adduced for this. These include a weakness in phagocytic and chemotactic activities of polymorphonuclear leucocytes, functional hyposplenism, defective opsonization, and recurrent ischemia. The MSS system is a major site of involvement with vasoocclusive episodes in  hemoglobinopathies. This propensity for decreased perfusion may increase the risk of bacterial invasion of these tissues in children suffering from SCD.

The most common bacterial pathogen in osteomyelitis in patients with SCD is controversial. Salmonella sp is usually considered the most prevalent organism associated with osteomyelitis in SCD. However, other reports have shown that Salmonella osteomyelitis may no longer be common in this condition. On the other hand, clinical experience has also shown that Gram-negative bacilli in orthopedic infections are increasing (unpublished data). This is supported by the report of Aken’Ova et al. in which 48% of the isolated organisms in osteomyelitis were Gram-negative bacilli. canadian discount drugs

The aim of the present study is to analyze the pattern of bacterial MSS infections in hospitalized children with and without abnormal genotype, as seen in our hospital. Also, it is to identify the types of infections and the associated bacterial pathogens and differences, if any, in the pattern of these infections in children with and without hemoglobinopathies, in a tertiary hospital setting.

About

So Many Advances in Medicine, So Many Yet to Come