HEMOGLOBINOPATHY AND PATTERN OF MUSCULOSKELETAL INFECTION IN CHILDREN: Patients and Methods

This study was carried out at the Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. All pediatric and adolescent patients admitted between January 1996 and December 2002 were identified from the admission records of the orthopedic and pediatric services. These were compared with the central medical records to ensure completeness of identification. All patients with bone and soft tissue infections were then selected. Sociodemographic data as well as data of clinical presentation, genotype, bacterial isolates, and hematological profile were studied. Specimens for bacteriological studies were swabs/aspirates of pus from wounds, sinus, or ulcer. Anaerobic cultures were not done during the study period.

No patient had HIV infection. Blood cultures were excluded from the analysis since blood stream infection (BSI) was not a subject of the present study. Diagnosis and differentiation between acute and chronic osteomyelitis (COM) were both clinical and radiological.
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Statistical analysis was done with Epi Info version 6 (Centers for Disease Control). Observed differences among patients groups were compared using Fisher’s exact test. A p value less than 0.05 was taken to be significant.

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